The Complete Oral Ketamine Reference
Everything about oral and tablet ketamine — how it works, Spravato, compounded options, finding prescribers, and what research says about oral administration.
Generic vs. Brand-Name Ketamine Options
Compare Ketalar, generic ketamine injection, Spravato esketamine, and compounded oral formulations — what distinguishes each and how to understand your options.
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Oral Ketamine
10Overview of oral and tablet ketamine forms, bioavailability, and history
How It Works
8Dosing, onset, duration, and pharmacokinetics of oral ketamine
Spravato Guide
8Complete guide to FDA-approved esketamine nasal spray for depression
Conditions
10Conditions treated with oral and tablet ketamine
Access & Cost
8Finding prescribers, telehealth options, insurance, and compounding
Research
8Clinical trials and scientific evidence on oral ketamine
FAQ
8Frequently asked questions about oral and tablet ketamine
Latest Articles
Generic vs. Brand-Name Ketamine Options
Compare Ketalar, generic ketamine injection, Spravato esketamine, and compounded oral formulations — what distinguishes each and how to understand your options.
How Pharmaceutical-Grade Oral Ketamine Is Made
Explore the manufacturing standards, quality controls, and key differences between pharmaceutical-grade and compounded oral ketamine, including GMP requirements.
FDA Considerations for Oral Ketamine
Understand the FDA's regulatory position on oral ketamine: off-label use, compounding regulations, DEA scheduling, and potential pathways to future approval.
History of Oral Ketamine Use in Medicine
Trace the history of oral ketamine from its 1970s anesthetic origins through palliative care applications to modern psychiatric use for treatment-resistant depression.
First-Pass Metabolism and Oral Ketamine
Learn how first-pass liver metabolism affects oral ketamine, why doses must be higher than IV, how norketamine is formed, and which factors alter this metabolic process.
Oral Ketamine Bioavailability Explained
Understand why oral ketamine has only 10-25% bioavailability compared to 90%+ for IV, how first-pass metabolism works, and what this means for your treatment.
Compounded Oral Ketamine: What You Need to Know
Everything patients need to know about compounded oral ketamine: 503A pharmacy regulations, ingredients, how compounding works, and how to access it safely.
Immediate vs. Extended-Release Oral Ketamine
Compare immediate-release and extended-release oral ketamine formulations, their clinical applications, pharmacokinetic profiles, and which patients benefit most from each.
Medical Disclaimer
The information on this website is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making decisions about your health or treatment options.